From the phenotype point of view, variants in GRIN2A are predominantly associated with a more definite phenotype characterized by an epileptic spectrum ranging from Landau–Kleffner syndrome to benign childhood epilepsy with centrotemporal spikes, epileptic encephalopathy, atypical childhood epilepsy with centrotemporal spikes (ACECTS), and benign childhood epilepsy with centrotemporal spikes (BECTS) often associated with DD/ID [4,5]. Here, GRIN2A is linked to Epileptic encephalopathy.