In two large, randomized phase III studies, each lasting 26 weeks, 648 COPD patients were genotyped for four polymorphisms in the ADRB2 gene: Arg16Gly, Thr164Ile, Gln27Glu, and a variant in the 5′ untranslated region (rs1042711). The gene discussed is ADRB2; the disease is chronic obstructive pulmonary disease.