In this particular case, FMR1-Antisense RNA 1 (Fragile X Mental Retardation 1 Antisense RNA 1, FMR1-AS1) seems to be involved in silencing of FMR1, especially in the context of Fragile X syndrome, wherein the expansion of CGG repeats leads to DNA methylation and gene silencing. This evidence concerns the gene FMR1 and fragile X syndrome.