Out of over 1028 patients included in the Emilia Romagna Register for ALS and tested for at least the four main genes related to ALS, 67 (6.52%) showed C9ORF72 expansion, whereas 894 (86.96%) did not show any further mutation in SOD1, FUS, or TARDBP genes. Here, SOD1 is linked to amyotrophic lateral sclerosis.