SIGLEC8 and psoriasis: On the other side, CCR3 (receptor for CCL11), together with seven other genes (SIGLEC8, IL5RA, RNASE2, CPA3, GATA2, c-KIT, and PRSS33), was identified as a potential diagnostic biomarker and therapeutic target for psoriasis using highly sophisticated Weighted Gene Co-expression Network Analysis (WGCNA) [13].