The most frequently mutated tumor suppressor gene in gastric and many other cancers, TP53, encoded for p53, was commonly mutated in both groups with a higher prevalence in the group with SOX2 maintenance of expression (61.9% versus 49.6% in the group with suppressed SOX2 expression) which approached statistical significance (Fisher’s exact test with p = 0.07). This evidence concerns the gene TP53 and cancer.