ABCB4 and gallbladder disease 1: Genetically determined ABCB4 deficiency or dysfunction can cause liver diseases such as phospholipid-associated cholelithiasis syndrome (LPAC), progressive familial intrahepatic cholestasis type 3 (PFIC 3), drug-induced liver injury (DILI), intrahepatic cholestasis of pregnancy (ICP), chronic cholangiopathy, adult biliary fibrosis or cirrhosis, transient neonatal cholestasis, and parenteral nutrition-associated liver disease.