Although stimulating CLL cells with specific agents such as CpG oligodeoxynucleotides (CpG ODNs), interleukin 2 (IL-2), pokeweed mitogen (PWM), phytohemagglutinin (PHA), lipopolysaccharides (LPSs) [10,11,17,18,19,21,22,23], and even Epstein–Barr virus (EBV) [17] has increased the detection of chromosomal abnormalities, those alterations smaller than 1 Mb remain undetected through karyotyping. Here, IL2 is linked to B-cell chronic lymphocytic leukemia.