CRYAB and myopathy: Comparatively, the only Online Mendelian Inheritance in Man (OMIM) disease pathway upregulated in simvastatin-treated muscle cells was myopathy, a general term for muscle weakness or dysfunction, with nine unique genes mapped to this pathway, including PGAM2, NEB, DES, TNNT1, CRYAB, MYH7, MYF6, DYSF, and ATP2A1.