Gain-of-function mutations or upregulation of PYGM (Muscle Glycogen Phosphorylase) and PGAM2 (Phosphoglycerate Mutase 2) give rise to glycogen storage diseases, resulting in severe muscle weakness, exercise intolerance, and an increased risk of muscle injury [114,115,116]. This evidence concerns the gene PGAM2 and Glycogen storage disease due to glycogenin deficiency.