Comparatively, the only Online Mendelian Inheritance in Man (OMIM) disease pathway upregulated in simvastatin-treated muscle cells was myopathy, a general term for muscle weakness or dysfunction, with nine unique genes mapped to this pathway, including PGAM2, NEB, DES, TNNT1, CRYAB, MYH7, MYF6, DYSF, and ATP2A1. The gene discussed is PGAM2; the disease is myopathy.