The upregulation of DYSF (Dysferlin) has previously been shown to be associated with muscle weakness and irregular gait while mutations in this gene have been linked to various myopathies, including limb-girdle muscular dystrophy type 2B and Miyoshi myopathy [112,113]. This evidence concerns the gene DYSF and autosomal recessive limb-girdle muscular dystrophy type 2B.