Finally, another study from China proposed scores which incorporated cfDNA fragmentation, motif scores and nucleosomes with an established HCC risk score (aMAP) and AFP achieving excellent diagnostic accuracy for HCC diagnosis (AUROC: 0.85–0.89) with good sensitivity (67–70%) and excellent specificity (88–92%) in both the training and validation cohorts [52]. This evidence concerns the gene AFP and hepatocellular carcinoma.