In murine tumor models of transplanted melanoma (B16-cEGFR), colorectal carcinoma (MC38-cEGFR), lung cancer (TC1-cEGFR), and human epidermoid carcinoma (A431-cEGFR)—where „cEGFR” indicates that these cancer cells were engineered to express a chimeric EGFR—CmAb-(IL-10)2 effectively extended the half-life of IL-10 without inducing toxicity. This evidence concerns the gene EGFR and colorectal carcinoma.