IL10RA and neoplasm: The key determinants of the paradox tumor-promoting and anti-tumor properties of IL-10 include tumor type, the tumor microenvironment (TME) context, IL-10 sources, concentration, and intratumoral persistence, IL-10R expression levels and binding affinities, activation of JAK/STAT downstream signaling pathways on tumor and immune cells, and the intricate interplay between IL-10 and other immunoregulatory molecules within the TME [21,22,23,24,25,26].