SIRT1 effects on forkhead box protein O1 (FOXO1), signal transducer and activator of transcription 5 (STAT5)—related pathways, and tyrosine kinases like BCR-ABL, promoting leukemogenesis in chronic myeloid leukemia (CML), have also been described [57,58]. The gene discussed is FOXO1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.