Specifically, 18 out of 46 (39%) tumors from patients with metastasis on biopsy, or those who developed metastatic disease, were positive for maximum (3+) p53 staining, compared to 0 out of 38 (0%) tumors from patients without metastatic disease (p < 0.001) (Table 2). Here, TP53 is linked to metastatic neoplasm.