We have shown before that in radical prostatectomy (RP) specimens from patients with PCa, high levels of p53 nuclear expression was suggestive of the presence of pathogenic TP53 alterations, and, together with lymphovascular invasion (LVI) status, enhances the early prognostication of PCa progression and development of metastatic disease [26]. The gene discussed is TP53; the disease is posterior cortical atrophy.