The downstream targets of STAT3 include anti-apoptotic genes (BCL-2, BCL-XL, MCL-1) [72], cell survival pathway genes (Cyclin-D1, Survivin) [73,74], drug efflux (MDR1) [75,76], and maintenance genes of cancer stem cells (CD133) [77,78]. The gene discussed is BCL2L1; the disease is cancer.