BCC is characterized by the expression of high-molecular-weight cytokeratins (HMWCKs) like CK-AE1/AE3, CK-5/6, CK-14, BerEP4/EpCAM (a membrane glycoprotein absent in normal squamous epithelium or SCC), BCL2, p63, CD10 (positive in tumor cells and negative in stroma), androgen receptor (AR) and p53. The gene discussed is AR; the disease is neoplasm.