Kim et al. showed a mild increase in NF-L levels between baseline and 3 months of treatment in a cohort of 34 cancer patients treated with a paclitaxel-based regimen (median = 22.3 pg/mL); however, more pronounced changes were observed between 3 and 6 months of chemotherapy (median = 115.0 pg/mL) [31]. Here, NEFL is linked to cancer.