NEFL and neuropathy: However, the analysis of NF-L concentrations in CIPN G0 patients vs. patients with higher-grade neuropathies CIPN G2 and CIPN G3 showed that the area under the curve (AUC) was similar at 0.681 (95% CI-0.603–0.751), with a slightly higher cut-off point of 218 pg/mL and a significance level of p = 0.0008 (Figure 4).