RPTOR and type 2 diabetes mellitus: With the in silico analysis of the RPTOR the rs12946618, rs12946115, and rs12950541 variants, we found that the degradation of mRNA RPTOR via the NMD process, and as a consequence, a deficient expression level of RPTOR protein in homozygous and heterozygous carriers, can be the factor associated with T2D development because RPTOR is required for maintaining a β-cell identity as well as repressing β-cell to α-cell transdifferentiation [107].