We found the association of 12 genetic variants located in the DRD4, PPARG, PON1, TCF7L2, MMP8, FTO, RPTOR, and SCAF4 genes, and the non-coding regions in SCT, DEAF1, KCNJ11, ABCC8, AMZ2P1, and GNA13, with risk of BC, menopause, and BMI in Northeastern Mexico. Here, SCAF4 is linked to breast cancer.