Our 2L sorafenib data confirmed AFP levels ≥ 400 ng/mL (HR 2.201, 95% CI: 1.244–3.894) and extrahepatic spread (HR 1.865, 95% CI: 1.064–3.270) as prognostically relevant but failed to confirm cirrhosis etiology or any other above-mentioned factors. Here, AFP is linked to Cirrhosis.