KLK3 and neoplasm: Previously identified factors predicting BCR include initial prostate-specific antigen (iPSA), positive surgical margins (PSM), gleason scores (GS), pathological tumor stage (pT), body mass index (BMI), family history (FH), age and D’Amico classification, which categorizes patients into low, intermediate, and high-risk groups based on clinical tumor stage (cT), GS, and initial prostate-specific antigen (iPSA) [2,3,4,5,6,7].