Furthermore, EV-mediated transfer of miR-122-5p has been shown to regulate PMN formation by modulating cell–ECM adhesion; it upregulates N-cadherin and vimentin while downregulating E-cadherin in hepatocytes, as seen in non-small cell lung cancer (NSCLC) models [130]. The gene discussed is CDH1; the disease is non-small cell lung carcinoma.