In renal cell carcinoma (RCC), for example, a panel of mRNA markers (CUL9, KMT2D, PBRM1, PREX2, and SETD2) has been identified as a highly accurate classifier, distinguishing RCC from benign renal masses with an AUC of 0.83 [127]. Here, PREX2 is linked to renal cell carcinoma.