These compounds induce remarkable effects on human cancers by reducing the expression of a transcription factor regulating the expression of cytoprotective genes, reducing p53 activation, decreasing Bcl-2 expression and mitochondrial membrane potential, suppressing the expression of hypoxia-inducible factor 1 (HIF-1), and increasing cellular apoptosis with the downregulation of p-Akt expression [7]. This evidence concerns the gene AKT1 and cancer.