CASP3 and colorectal carcinoma: suppresses the growth of endothelial cells (Figure 4) in CRC, inhibiting the expression of RelA, Bcl2, caspase 3, and cyclin D1 (CCND1) and promoting apoptosis-related proteins Bcl-2-associated X (Bax), cleaved caspase 3, and EGFR [45].