CDH1 and colorectal carcinoma: Moreover, in a recent study, for the first time, it has been shown that the virulence factor FadA, from Fusobacterium nucleatum, interacts with E-cadherin, which is a cell surface molecule that mediates metastasis in CRC by activating an essential component of the Wnt/β-catenin signaling pathway, which is known to be the most damaged by mutations in CRC [63,83]