This analysis allows us to break down EC into four classes: POL-E mutated (POLE-mut); 8–10% of tumors, mismatch repair deficient (MMR-d); 25–30% of neoplasms, P53-abnormal (p53-abn)—copy number high (9% of tumors) and P53-wild type, copy number low, which is the largest group (NSMP) [5]. This evidence concerns the gene POLE and neoplasm.