TNF and neoplasm: Cluster 1 (left column), consisting of 75% of NR patients with PS > 0, was primarily characterized by elevated levels of several molecules (log2 Fold Change > 1.5, FDR < 0.05, limma modified t-test, Supplementary Table S4), including TNFα, IL1β, IL4, IL6, IL17, and CCL2, which are associated with an inflammatory network that supports tumor growth.