In this study, we measured the expression of fifteen HA-family members (HA, CD44, RHAMM, HAS-1, HAS-2, HAS-3, HYAL-1, and HYAL-4), and EMT markers (N-Cadh, β-catenin, TWIST1, SNAI1, Slug, MMP-9, and Vimentin) in normal colon and tumor specimens from two COAD patient cohorts and correlated the levels with clinical outcomes. Here, HYAL1 is linked to neoplasm.