Beyond ALS/FTD, TDP-43 pathology is increasingly linked to other neurological disorders including Limbic-predominant Age-related TDP-43 Encephalopathy (LATE), Alzheimer’s Disease (AD), Chronic Traumatic Encephalopathy (CTE), and Stroke [6–9]. This evidence concerns the gene TARDBP and early-onset autosomal dominant Alzheimer disease.