RHOA mutated gastric cancer cells reduced the secretion of CXCL10 and CXCL11, and stimulated the synthesis of fatty acids through the PI3K-AKT-mTOR pathway, which in turn enhances the inhibition of regulatory T cells (Tregs) within the TIME, thereby inducing immunosuppression [23]. The gene discussed is CXCL11; the disease is gastric cancer.