Our findings revealed that unlike other types of cancers, the expression of OBSCN was significantly negatively correlated with important parameters in the TIME of BLCA, such as TMEscoreB, TMEscoreA, Pan_F_TBRs, nucleotide_excision_repair, mismatch repair, immune checkpoint, EMT3, EMT2, DNA replication, DNA damage response, CD8+T effector, base excision repair, and antigen processing machinery, indicating the essential role of OBSCN expression deficiency in the immunoregulatory of BLCA (Fig. 4D). The gene discussed is OBSCN; the disease is cancer.