The possible reason for worse OS in BLCA patients with low OBSCN expression may be the functional exhaustion of CD8+T cells owing to the interaction of PD-L1/PD-1 axis between BLCA and CD8+T cells, which can be reactivated by using PD-1/PD-L1 ICIs. The gene discussed is CD8A; the disease is bladder transitional cell carcinoma.