For example, when AML (Acute Myeloid Leukemia, a malignant hematologic tumor derived from myeloid progenitor cells) [25] cells are stimulated to produce intracellular cAMP through amthamine, inhibiting the ABCC4-mediated efflux of cAMP via specific inhibitors significantly reduces the efficiency of AML cell proliferation [26, 27]. Here, ABCC4 is linked to acute myeloid leukemia.