Additionally, γδ T cells usually produce higher amounts of anti-tumor cytokines (such as TNF and IFN-γ) than pro-tumor cytokines (for instance: IL-4, IL-10, IL-17, IL-22, and IL-35) within the TME, reflecting their prognostic value in cancer patients [1, 102, 104]. The gene discussed is TNF; the disease is neoplasm.