S3). Genes such as FOS (c-FOS), CXCL8, and MAPK14 exhibited significant differences in the breast cancer group and were enriched in NETs-related pathways like Chemokine signaling pathway, IL-17 signaling pathway, and Toll-like receptor signaling pathway (Fig. 3E-G, Supplementary Tab. S3). This evidence concerns the gene CXCL8 and breast cancer.