*Two patients with two different subtype tumors; **two patients (three tumors) without information about TNM, G status; ***HER2: 2+ FISH (fluorescence in situ hybridization) negative; TNBC = triple negative breast cancer; HER2 = humane epithelial growth receptor 2 positive breast cancer; yr = year; ER = estrogen receptor; PR = progesterone receptor; Luminal B (estrogen receptors (ER+) and/or progesterone receptors (PR+)) with ki67 > 14%). The gene discussed is ESR1; the disease is breast carcinoma.