A correlation was found between plasma sCD27 levels and CD27-CD70 interaction or combined CD70-CD27 expression intratumorally in renal (Benhamouda et al, 2022) and nasopharyngeal carcinoma (Nagato et al, 2024), respectively, suggesting a tumor origin of plasma-soluble CD27. The gene discussed is CD27; the disease is nasopharyngeal carcinoma.