Unlike findings in renal cell carcinoma (Benhamouda et al, 2022), we found a predominant interaction between CD27 and CD70 expressed by stromal cells compared to tumor cells (Fig. 2B,D,E), even when considering only the interaction with CD8+T cells expressing CD27 (Fig. 2E). This evidence concerns the gene CD27 and hereditary clear cell renal cell carcinoma.