While it could have been argued that this was a consequence of ectopic overexpression or a specific property of the ASPSCR1-TFE3 fusion associated with more aggressive tumors (Prakasam et al, 2024; Sun et al, 2021), they are in agreement with our observations on endogenous NONO-TFE3 and PRCC-TFE3 proteins in tRCC cells. This evidence concerns the gene NONO and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.