High expression of NONO-TFE3 and lower expression of PRCC-TFE3 fusions in the corresponding tRCC lines was observed, while expression of native TFE3 in the other cell lines was variable, but considerably lower than the fusion proteins (Appendix Fig. S1A). Here, TFE3 is linked to renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.