Assessing their expression in NAT compared to tRCC clusters revealed that many key genes involved in ferroptosis resistance were up-regulated in tRCC compared to NAT (GPX4, GCLM, GCLC, SLC73A2, SLC7A11, TXNRD1), whereas those involved in promoting ferroptosis (TFRC, ASCL3, 4 and 6) were repressed (Fig. 6A; Appendix Fig. S6A). This evidence concerns the gene MFSD6L and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.