As previously observed in human tumors (Sun et al, 2021) and tRCC murine models (Prakasam et al, 2024), ASPSCR1-TFE3 tumors displayed a strong propensity for EMT, but tumors with other fusion partners also underwent EMT. Here, ASPSCR1 is linked to renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.