TFE3 and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions: Translocation renal cell carcinomas (tRCC) are characterized by genetic translocation events involving one member of the (MiT) family, most frequently TFE3 (90% of cases) (Bakouny et al, 2021; Caliò et al, 2019).