Additionally, it alleviates high glucose-induced oxidative stress and inflammation in podocytes by inactivating MAPK signaling through MMP12 inhibition28, and the anticancer effect of Forsythoside A in esophageal squamous cell carcinoma was approved29, which highlights its potential therapeutic value beyond just LOXL2 inhibition. The gene discussed is LOXL2; the disease is esophageal squamous cell carcinoma.