To determine if this was a specific effect in KMT2A-R leukemias or if DYRK1A also mediates hyperphosphorylation in other ALL subtypes, we performed a Western blot to measure and compare ERK phosphorylation levels in vehicle- or EHT1610-treated KMT2A-R ALL and non-KMT2A-R ALL cell lines and in KMT2A-R AML cell lines. The gene discussed is DYRK1A; the disease is acute lymphoblastic leukemia.