Concordant with our hypothesis, analysis of previously published ChIP-Seq data of KMT2A::AFF1 ALL cells demonstrated that both KMT2A and AFF1 directly bind to the promoter region of DYRK1A in ALL cell lines SEM and RS4;11 (Fig. 2A) [34, 35]. This evidence concerns the gene DYRK1A and acute lymphoblastic leukemia.