To evaluate if DYRK1A inhibition affects cell proliferation or induces apoptosis specifically in KMT2A-R ALL, we performed a cell cycle analysis before and after EHT1610 treatment, which resulted in a significant reduction of cells in S-phase (Fig. 4C) and minimal effects upon cell viability (Fig. 4D). The gene discussed is DYRK1A; the disease is acute lymphoblastic leukemia.