AFF1 and acute lymphoblastic leukemia: Using a meta-analysis of ChIP-Seq data from the ICN13 (KMT2A::AFF1) ALL PDX model, as well as the RS4;11 and SEM ALL cell lines (KMT2A::AFF1) [42], we found that BCL6 does not bind to the DYRK1A promoter (Supplementary Fig. 3B).