DYRK1A and leukemia: We also performed a gain-of-function meta-analysis of an Eμ-myc transgenic lymphoma/leukemia model [46, 47] (Fig. 3F) and observed that increased Myc levels correlate with decreased Dyrk1a levels during in vivo leukemia progression, further confirming a negative regulation of Dyrk1a via Myc.