NUP214 and acute myeloid leukemia: The pathogenesis of DEK::NUP214 AML has been investigated using human CD34+ human hematopoietic progenitor cells transduced with DEK::NUP214 xenografted into immunocompromised mice as well as syngeneic murine models [11, 12], but models which allow serial transplantation of human AML cells, which would enable pharmacologic testing of new treatment approaches, have not been described so far.