Functional investigation of the role of XPO1 in DEK::NUP214 AML showed that the oncogenic function of DEK::NUP214 depends on XPO1, as deletion of XPO1 led to cell cycle arrest and apoptosis in vitro, while pharmacologic inhibition of XPO1 by eltanexor cured PDX mice from DEK::NUP214 AML. The gene discussed is XPO1; the disease is acute myeloid leukemia.