The pathogenesis of DEK::NUP214 AML has been investigated using human CD34+ human hematopoietic progenitor cells transduced with DEK::NUP214 xenografted into immunocompromised mice as well as syngeneic murine models [11, 12], but models which allow serial transplantation of human AML cells, which would enable pharmacologic testing of new treatment approaches, have not been described so far. Here, CD34 is linked to acute myeloid leukemia.