Similarly, a pathway enrichment analysis demonstrated the involvement of these transcripts in pathways related to GBM, such as the interferon regulatory transcription factor 3 (IRF3)-Interferon (IFN) cascade, components of the innate immunity system (Pattwell and Holland, 2017), ROBO receptors involved in cell migration and invasion (Markouli et al, 2024; Geraldo et al, 2021) and β-oxidation of fatty acids that is critical for the metabolic adaptation of GBM cells (Miska and Chandel, 2023) and a valuable therapeutic target (Lin et al, 2017) (Fig. 7K, right panel; Dataset EV9). The gene discussed is IRF3; the disease is glioblastoma.