When si-hsa_circ_0074763 was transfected into LX-2 cells, qRT - PCR and Western blot were used to detect the HF indicators α - SMA and COL1A1, and the mRNA and protein levels of α - SMA and COL1A1 were significantly reduced (Fig. 4A-J). Here, COL1A1 is linked to hydrops fetalis.