COL1A1 and Hepatic fibrosis: Activated hepatic stellate cells are the main cellular source of ECM, accounting for approximately 90% of ECM, ultimately giving rise to myofibroblasts4 .The main components of ECM are COL1A1 (Collagen type I alpha 1) and COL1A3 (Collagen Type III), thus inhibiting the activation of hepatic stellate cells and the production of collagen is key to treating and preventing liver fibrosis.