For several solid tumors with high levels of CXCL8, including pancreatic, breast, and ovarian cancer cells, enforced expression of CXCR1 or CXCR2 in A20-28z CAR-T cells showed a higher infiltration proportion in the tumor core, with altered specificity or cytolytic activity [51] (Fig. 3G). Here, CXCL8 is linked to neoplasm.