SPINK7 deficiency results in the unleashing of proteolytic activities and proinflammatory innate responses in oesophageal epithelium through regulating uPA and kallikrein 5 (KLK5), which makes significant contributions to eosinophilic esophagitis (EoE) pathogenesis.27, 28. This evidence concerns the gene SPINK7 and eosinophilic esophagitis.