CD4 and neoplasm: For this reason, we evaluated the ratios between tumor-infiltrating lymphocyte subtypes and tumor-associated macrophages, proposing the following relationships: cytotoxic and helper T lymphocytes (CD8+ T cell/ CD4+ T cell), cytotoxic T lymphocyte and M0 macrophages (CD8+ T cells/ CD68+) and M0 and M1-polarized macrophages (CD68+ / L1.MAC387+).