Within the context of CVB3-induced myocarditis, blunting expression of TNF-ɑ and IFN-ɣ in vivo via treatment with atorvastatin, a 3-hydroxy-3-methylglutaryl co-enzyme A (HMG-CoA) inhibitor, rescued cardiac expression and localization of Cx43 and Cx45 [48]. This evidence concerns the gene GJA1 and myocarditis.