Xu et al. [5] showed that mature IL-1β, IL-18 and other DAMPs are released into the extracellular space, which further activates TAK1 to initiate a new round of TAK1-p38MAPK-NLRP3 inflammatory pathway activation, expands the inflammatory response, exacerbate inflammatory damage in the heart, and induce severe ventricular arrhythmia. This evidence concerns the gene IL18 and Ventricular arrhythmia.