SMC-specific deletion of Jmjd3 in mice (Jmjd3fl/flMyh11CreERT) resulted in increased BP in an angiotensin II (Ang II) model of HTN, which was due to decreased EDNRB and increased EDNRA, genes encoding expression of EDNRA and EDNRB, respectively, in SMCs. The gene discussed is EDNRB; the disease is hypertensive disorder.