PDGFRA and neoplasm: Unsupervised cluster analysis of 68 GISTs (i.e., 28 GISTs from the current study, and 40 external GISTs for which only age, sex, tumor location, and in three cases mutation status were available) revealed a predominant DNA methylation clustering pattern based on anatomical location (stomach vs. small intestine vs. rectosigmoid; Figure 1A) and genotype (KIT vs. PDGFRA vs. SDH‐deficient; Figure 1B).