It was reported that STAT1 pathway mediated CD38 upregulation on myeloma cells and endothelial cells.[21] We found that the expression of CD38 in monocytes stimulated with LPS and IFN‐γ or MGO was significantly reduced by fludarabine as a STAT1 specific inhibitor (Figure 7M), and MGO treatment also directly activated STAT1 phosphorylation (Figure 7N), which suggesting MGO upregulates STAT1 phosphorylation and facilitates CD38 expression. The gene discussed is STAT1; the disease is plasma cell myeloma.