We next isolated mouse peripheral monocytes and found that sepsis‐induced CD38 activation was significantly reduced with 78c intervention at 3 h after modeling (Figure S7D, Supporting Information), and observed the NAD+ levels were rescued, whereas the expression levels of HIF‐1a were significantly reduced with 78c intervention at 3 and 6 h after modeling (Figure S7E,F, Supporting Information), which demonstrated the role of CD38‐NAD+ ‐HIF‐1α‐glycolysis axis in monocytes of septic mice. The gene discussed is HIF1A; the disease is Sepsis.