The translation of circRNAs into proteins has attracted increasing attention in recent years.[22] These resulting proteins have been shown to exert strong biological functions and have been regarded as new protein isoforms specifically encoded by circRNAs.[38, 39, 40] NAB1‐356 exhibited regulatory effects on fibrosis and cytokine expression, which are the key factors in AF development.[41] Our study adds to the growing body of evidence supporting the functional significance of circRNA translation, demonstrating the key role of the resulting protein in cardiovascular health and disease. Here, NAB1 is linked to atrial fibrillation.