ITGAM and neoplasm: Notably, we uncovered a non‐monocytic origin of anti‐tumor trained immunity: in contrast to the predominant focus on bone marrow‐derived monocytes/macrophages, we demonstrate that splenic CD11b+ cells—including neutrophils and dendritic cell subsets—serve as the primary mediators of KK2DP7‐induced training, challenging current paradigms.