Further analysis revealed that YY1 knockdown increased the expression of E‐cadherin (an epithelial marker) and decreased that of Vimentin (a mesenchymal marker) (Figure 6B), indicating that YY1 promotes EMT in CRC cells, potentially through Snail1 (Figure 6B,C), a key regulator of EMT. This evidence concerns the gene CDH1 and colorectal carcinoma.