For example, it reduces cell viability in oral squamous cell carcinoma, inhibits proliferation and migration in intrahepatic cholangiocarcinoma, and suppresses the growth of mouse cholangiocarcinoma tumors.[63, 64] In our study, inhibition of CXCR2 with SB225002 confirmed that CRC cell recruitment of SCs is dependent on the CXCL1/CXCR2 axis. The gene discussed is CXCL1; the disease is cholangiocarcinoma.