MAGEA6 interacts with the transcription factor Yin‐Yang 1 (YY1), which subsequently increases the secretion of CXCL1 by CRC cells, facilitates the recruitment of CRC cells to SCs, while also enhancing tumor cell invasiveness through epithelial‐mesenchymal transition (EMT), ultimately promoting PNI. This evidence concerns the gene MAGEA6 and colorectal carcinoma.