YY1 and neoplasm: [71, 72] Snail1, a key transcription factor, suppresses metastasis‐suppressor proteins such as E‐cadherin and Claudins while promoting mesenchymal markers like N‐cadherin, Vimentin, and Fibronectin, thereby inducing EMT and enhancing the migratory and invasive capabilities of tumor cells.[73, 74] Interventions targeting YY1 expression or activity may disrupt EMT, inhibiting tumor migration and invasion.[75] Our study validated that downregulation of YY1 expression led to reduced EMT in CRC cells, which resulted in decreased migration and invasion capabilities in vitro.