SYK and acute kidney injury: Curcumin is known to significantly downregulate the level of macrophage Mincle after AKI, promoting the transition of the macrophage phenotype from M1 to M2, and intervening in AKI by blocking the triggering of Mincle downstream factors spleen tyrosine kinase and nuclear factor κB.[129] Nevertheless, the limited solubility and permeability of curcumin severely restrict its potential use in the therapy of AKI.