This is thought to be a result of IL‐10‐mediated inhibition of the innate immune system.[88] Moreover, Jaworska and colleagues observed improvement in IRI following Treg transfer, an effect dependent on the expression of programmed death ligands 1 and 2 (PD‐L1/2) by Tregs.[89] Therefore, increasing the number of renal Tregs and enhancing Treg activity represent novel targets for AKI immunotherapy. Here, IL10 is linked to acute kidney injury.